Digital olfaction predicts mosquito behaviour

By Koen Dechering18/09/202201/11/2022 News deep learning, digital olfaction, mosquito, repellents, ticks

From our collaborative work with computational scientists at Google Brain, two exciting preprints have been released on BioRxiv. The first describes an accurate model for odor perception that…

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out

By Koen Dechering29/07/202223/08/2022 Publications

K. Dechering et al., SLAS Discovery (22), 2022 ABSTRACT A central challenge of antimalarial therapy is the emergence of resistance to the components of artemisinin-based combination therapies (ACTs)…

TropIQ presents at the Drug Design and Development seminar in Munich

By Koen Dechering20/06/202201/11/2022 News

TropIQ will contribute two oral presentations to the 2022 Drug Design and Development Seminar of the German Society for Parasitology: Analysis of tick regurgitation following mechanical, cryogenic and…

MMV, PPSC and TropIQ present a webinar on state of the art in malaria phenotypic screening

By Koen Dechering20/05/202229/07/2022 News

On June 22nd at 4 pm CET, the Medicines for Malaria Venture, the Pivot Park Screening Centre and TropIQ will present a webinar on their collaborative work in…

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

By Koen Dechering21/04/202223/08/2022 Publications

L.E. de Vries et al., Nature Communications 13(1), 2022 ABSTRACT Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183…

Antimalarial MMV’183 is a clinical development candidate

By Koen Dechering20/04/202229/07/2022 News

TropIQ’s parasitology platform drove the optimisation of pantothenamide compounds that generated MMV’183: a candidate for further clinical development with a new mode of action for treatment of malaria and…

The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity

By Koen Dechering29/01/202223/08/2022 Publications

G. Siciliano et al., Pharmaceuticals 15(2), 2022 ABSTRACT This work describes the activity of 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX) and of its newly identified carboxylic acid metabolite on the human malaria…

TropIQ publishes innovative mosquito barcoding technology

By Koen Dechering21/12/202129/07/2022 News

We present a barcoding strategy that enables phenotypic screens of blood-feeding insects against small molecules in microtiter plate-based arrays and apply this to discovery of novel systemic insecticides…

Barcoded Asaia bacteria enable mosquito in vivo screens and identify novel systemic insecticides and inhibitors of malaria transmission

By Koen Dechering21/12/202129/07/2022 Publications

A. Sturm et al., PLOS Biology 19(12) 2021 ABSTRACT This work addresses the need for new chemical matter in product development for control of pest insects and vector-borne…

TropIQ Digitalises Its Discovery Platform with CDD Vault

By Koen Dechering13/10/202014/10/2020 News

CDD Vault will enable TropIQ Health Sciences to share research results with partners in real time Nijmegen and San Francisco — October 8, 2020 TropIQ Health Sciences, a…