Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Kato N, et. al., Nature. 2016 Oct 20 ABSTRACT Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of action could be discovered using a diverse collection of synthetic compounds that have three-dimensional features reminiscent of natural products and…

TropIQ staff co-authors paper in Nature

Nature publishes the paper ‘Diversity-oriented synthesis yields novel multistage antimalarial inhibitors’ that is co-authored by TropIQ staff. Antimalarial drugs have thus far beenchiefly derived from two sources—natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of action could be discovered using a diverse collection of synthetic compounds that have…