Our liver stage platform supports life cycle profiling for new anti-malarial. By Angelika Sturm15/06/202131/08/2021 Categories: News In the battle against malaria new drugs are needed. This publication identified 1-(pyridine-4-yl)pyrrolidine-2-one derivates as a novel, dual stage active (asexual blood stages and liver stage), anti-malaria. read…
Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors By Angelika Sturm15/06/202131/08/2021 Categories: Publications Okaniwa et al., ACS Infect Dis. 2021 jun 11 ABSTRACT Prolyl-tRNA synthetase (PRS) is a clinically validated antimalarial target. Screening of a set of PRS ATP-site binders, initially…