TropIQ scientists co-authored a publication on a new approach to eliminate malaria by blocking cyclic nucleotide catabolism. The paper was published by Science Advances. It describes small molecules that block the action of phosphodiesterases, enzymes that regulate the levels of a key signalling molecule in malaria parasites. Blocking these enzymes kills the stage of the parasite that causes clinical disease and also blocks infection of mosquitoes. The latter is an important feature for development of novel drugs to eliminate malaria. TropIQ contributed key data on these transmission-blocking properties and helped to unravel the mechanisms by which malaria parasites may gain resistance against these molecules.
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