TropIQ published a paper resulting from a collaboration with a group of talented colleagues from Burkina Faso and the Netherlands. It builds on the concept of developing isoxazolines as mosquitocidal drugs for reduction of malaria disease incidence. It shows that the killing effect of isoxazolines is not affected by the sugar meal that a mosquito takes, or by antibiotic treatment. Both sugars and antibiotics lead to changes in the mosquito microbiome, that may play a role in metabolism of drugs. Our data indicate that the efficacy of isoxazolines is unlikely to be affected by changes in microbiome and that these compounds may be active across a range of habitats and mosquito feeding patterns. It provides important validation of previous laboratory findings.
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