Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases

Miglianico M. et al., PNAS 2018 July 02 ABSTRACT Isoxazolines are oral insecticidal drugs currently licensed for ectoparasite control in companion animals. Here we propose their use in humans for the reduction of vector-borne disease incidence. Fluralaner and afoxolaner rapidly killed Anopheles, Aedes, and Culex mosquitoes and Phlebotomus sand flies after feeding on a drug-supplemented…