An inter-laboratory comparison of standard membrane-feeding assays for evaluation of malaria transmission-blocking vaccines.

Miura K. et al.,Malar J. 2016 Sep 9 ABSTRACT BACKGROUND: An effective malaria transmission-blocking vaccine may play an important role in malaria elimination efforts, and a robust biological assay is essential for its development. The standard membrane-feeding assay (SMFA) for Plasmodium falciparum infection of mosquitoes is considered a “gold standard” assay to measure transmission-blocking activity…

TropIQ staff co-authors paper in Nature

Nature publishes the paper ‘Diversity-oriented synthesis yields novel multistage antimalarial inhibitors’ that is co-authored by TropIQ staff. Antimalarial drugs have thus far beenchiefly derived from two sources—natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of action could be discovered using a diverse collection of synthetic compounds that have…