A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Phillips MA et al., Sci Transl Med. 2015 Jul 15 ABSTRACT Malaria is one of the most significant causes of childhood mortality, but disease control efforts are threatened by resistance of the Plasmodium parasite to current therapies. Continued progress in combating malaria requires development of new, easy to administer drug combinations with broad-ranging activity against…

Analysis of a Multi-component Multi-stage Malaria Vaccine Candidate–Tackling the Cocktail Challenge.

Boes A, et al., PLoS One. 2015 Jul 6 ABSTRACT Combining key antigens from the different stages of the P. falciparum life cycle in the context of a multi-stage-specific cocktail offers a promising approach towards the development of a malaria vaccine ideally capable of preventing initial infection, the clinical manifestation as well as the transmission…